Diadenosine polyphosphate analogue controls postsynaptic excitation in CA3-CA1 synapses via a nitric oxide (NO)-dependent mechanism
نویسندگان
چکیده
Department of Cellular Membranology, Bogomoletz Institute of Physiology, Bogomoletz Str. 4, Kiev, Ukraine 01204 (S.M., T.T., V.T., N.L.), Imperial College Genetic Therapies Centre, Department of Chemistry, Flowers Building, Armstrong Road, Imperial College London, South Kensington, London SW7 2AZ, UK (M.W., J.A.T., A.D.M.) JPET Fast Forward. Published on May 18, 2006 as DOI:10.1124/jpet.105.097642
منابع مشابه
Diadenosine polyphosphate analog controls postsynaptic excitation in CA3-CA1 synapses via a nitric oxide-dependent mechanism.
Previously, we have described the modulatory effect of diadenosine polyphosphates Ap4A and Ap5A on synaptic transmission in the rat hippocampal slices mediated by presynaptic receptors (Klishin et al., 1994). In contrast, we now describe how nonhydrolyzable Ap4A analog diadenosine-5',5'''-P1,P4-[beta,beta'-methylene]tetraphosphate (AppCH2ppA) at low micromolar concentrations exerts strong nonde...
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